Our Stories: Michelle Linterman
“I guess most people don’t think about this very beautiful, coordinated cellular response to make antibodies…” Michelle Linterman’s passion for her subject is immediately obvious. Born and bred on the Kapiti Coast, Michelle is a globally-renowned immunologist at the Babraham Institute, a site for biomedical research centred around an old red-brick manor house in a rolling natural landscape just outside Cambridge. This picturesque English setting provides the research group she established ten years ago with cutting-edge laboratory facilities for testing responses to new vaccines. Early in the pandemic, Michelle’s ten-person team at the Babraham ran an important preclinical study of the Oxford AstraZeneca vaccine in aged mice, in order to test - faster than could be tested in ageing humans - how that vaccine would act in older bodies.
The Linterman Group’s wider research programme centres on the “nuts and bolts” of how the immune system mounts a good response against vaccination, and why vaccines don’t always work as well for certain age groups. Michelle’s team tests the detailed cellular and molecular functioning of vaccines against a range of human diseases, such as malaria and influenza.